Method Of Wet Grinding Pharmaceutical Substances

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US5862999A - Method of grinding pharmaceutical

A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.WO1995031974A1 - Method of grinding pharmaceutical,,Discuss; 238000000227 grinding Methods 0.000 title claims abstract description 49; 239000000126 substances Substances 0.000 title description 7; 239000002245 particles SubstancesAU660852B2 - Method of grinding pharmaceutical,AU660852B2 AU48670/93A AU4867093A AU660852B2 AU 660852 B2 AU660852 B2 AU 660852B2 AU 48670/93 A AU48670/93 A AU 48670/93A AU 4867093 A AU4867093 A

EP0760653A1 - Method of grinding pharmaceutical

EP0760653A1 EP19950919828 EP95919828A EP0760653A1 EP 0760653 A1 EP0760653 A1 EP 0760653A1 EP 19950919828 EP19950919828 EP 19950919828 EP 95919828 A EP95919828 A EP,Tablet Manufacture by Wet Granulation Method,,A method of preparing particles of a drug substance which comprises grinding said substance with rigid grinding media to reduce said particles to submicron size wherein the grinding media have a substantially spherical shape, a particle size range of 0.1 to 3 mm. and consist essentially of a polymeric resin or of a core having adhered thereon a coating of the polymeric resin.Method of grinding pharmaceutical substances - US Patent,Method of grinding pharmaceutical substances Abstract. A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.

EP0600528A1 - Method of grinding pharmaceutical

EP0600528A1 EP93202795A EP93202795A EP0600528A1 EP 0600528 A1 EP0600528 A1 EP 0600528A1 EP 93202795 A EP93202795 A EP 93202795A EP 93202795 A EP93202795 A EP,method of wet grinding pharmaceutical substances,,Method of grinding pharmaceutical substances this invention is practiced in accordance with the wet-grinding » More detailed! Method of grinding pharmaceutical substances. Method of grinding pharmaceutical substances Abstract. A method of preparing submicron method of claim 1, wherein said method is a wet grinding process. 4. The,Tablet Manufacture by Wet Granulation Method,,Wet granulation method is a process of size enlargement in which fine powder particles are agglomerated or brought together into larger, strong and relatively permanent structure called granules using a suitable non-toxic granulating fluid such as water, isopropanol or ethanol (or mixtures thereof). The granulating fluid can be used alone or as a solvent containing binder or granulating agent,

Method of grinding pharmaceutical substances - US

Method of grinding pharmaceutical substances Abstract. A method of preparing particles of a drug substance or diagnostic imaging agent which comprises grinding the drug substance or imaging agent in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.US Patent for Method of grinding pharmaceutical,Method of grinding pharmaceutical substances . Jun 15, 1995 - Nano Systems L.L.C. A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine,METHOD OF GRINDING PHARMACEUTICAL,A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.

Method of grinding pharmaceutical substances - Patent,

A method of preparing particles of a drug substance, which may be a diagnostic imaging agent, which comprises grinding the drug substance in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.METHOD OF GRINDING PHARMACEUTICAL,A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.Wet milling - IKA,The wet milling of such substances with rotor-stator machines offers a multitude of advantages: The resulting fine fraction is bonded directly in the suspension, so that a dust formation is avoided from the outset. The substances to be ground remain in the system, unlike dry systems, allowing for a significant reduction of losses. Therefore, wet milling is well-suited for organic chemistry,

CONTINUOUS METHOD OF GRINDING

The method enables the use of fine grinding media, e.g., of a particle size of less than about 300 'mu'm, in a continuous grinding process which provides extremely fine particles of the agent, e.g., particles less than 100 nm in size, while avoiding problems, e.g., separator screen plugging, associated with prior art processes requiring the separation of agent from the grinding media in the,Tablet Manufacture by Wet Granulation Method,,Wet granulation method is a process of size enlargement in which fine powder particles are agglomerated or brought together into larger, strong and relatively permanent structure called granules using a suitable non-toxic granulating fluid such as water, isopropanol or ethanol (or mixtures thereof). The granulating fluid can be used alone or as a solvent containing binder or granulating agent,method of wet grinding pharmaceutical substances,,Method of grinding pharmaceutical substances this invention is practiced in accordance with the wet-grinding » More detailed! Method of grinding pharmaceutical substances. Method of grinding pharmaceutical substances Abstract. A method of preparing submicron method of claim 1, wherein said method is a wet grinding process. 4. The,

Method of grinding pharmaceutical substances - Patent,

A method of preparing particles of a drug substance, which may be a diagnostic imaging agent, which comprises grinding the drug substance in the presence of grinding media comprising a polymeric resin. The method provides particles exhibiting reduced contamination.(PDF) Pharmaceutical Granulation Processes,,The wet granulation process has been impacted over the last 25 years by the development of improved equipment, innovative research, novel polymeric binders, and even Process Analytical,advantages of wet ball milling method,Apr 03, 2020 Wet granulation method of tablet production involves the following processing steps: Step 1: Weighing and mixing of formulation ingredients (excluding the lubricant). This step involves the weighing, sifting and introduction of specified quantities of drug substance(s), bulking agent, filler or diluent, and disintegrant into a powder mixer.

METHOD OF GRINDING PHARMACEUTICAL

A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.Wet chemistry - Wikipedia,Wet chemistry is a form of analytical chemistry that uses classical methods such as observation to analyze materials. It is called wet chemistry since most analyzing is done in the liquid phase. Wet chemistry is also called bench chemistry since many tests are performed at lab benches. Materials. Wet chemistry commonly uses laboratory glassware such as beakers and graduated cylinders to,Continuous method of grinding pharmaceutical,The method enables the use of fine grinding media, e.g., of a particle size of less than about 300 .mu.m, in a continuous grinding process which provides extremely fine particles of the agent, e.g., particles less than 100 nm in size, while avoiding problems, e.g., separator screen plugging, associated with prior art processes requiring the,

Chapter 6 Wet Grinding in Stirred Media Mills | Request

Grinding and dispersing in stirred media mills is a process, which is widely used in different industries such as chemical, ceramic, pharmaceutical, filler, ink and cosmetic industry. Stirred,EP 0804161 B1 20011107 - CONTINUOUS METHOD OF,298995427 - EP 0804161 B1 20011107 - CONTINUOUS METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES - [origin: WO9531973A1] A continuous method of preparing submicron particles of a therapeutic or diagnostic agent comprises the steps of continuously introducing the agent and rigid grinding media into a milling chamber, contacting the agent with the grinding media while in the,

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